1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi

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• 作者：Marinela Rodrí ; guez-Ciria ; Ana M. Sanz ; Marí ; a J.R. Yunta ; Fern ; o Gó ; mez-Contreras ; Pilar Navarro ; Manuel Sá ; nchez-Moreno ; Samira Boutaleb-Charki ; Antonio Osuna ; Alfonso Castiñ ; eir
• 关键词：1 ; 4-Bis(alkylamino)benzo[g]phthalazines ; Trypanosoma cruzi SOD inhibitors ; Dinuclear copper complexes ; OH endogenous bridges ; Antiparasitic activity
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2007
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：1 March 2007
• 卷：15
• 期：5
• 页码：2081-2091
• 文件大小：291 K

摘要

The synthesis of a new series of 1,4-bis(alkylamino)benzo[g]phthalazines 1–3 is reported, and their ability to form dinuclear complexes with Cu(II) assayed. The geometry of the complexes is dependent on the nature of the electron-donor sites at the sidechains. Compounds 1 and 2, that contain spp>3p> or spp>2p> nitrogens at the end of the alkylamino groups, originate monopodal dinuclear complexes which seem to include endogenous OH bridges, and the sidechains seem to actively participate in complexation. However, the substitution of nitrogen by oxygen in 3 leads to a tripodal dinuclear complex in which the sidechains are not involved. The in vitro antiparasitic activity on Trypanosoma cruzi epimastigotes and amastigotes and the SOD activity inhibition have been evaluated for compounds 1–3, and, as expected, 1 and 2 show in all cases relevant results, whereas 3 is always the less active among the three substrates tested.