• 作者：R. Sanz-Requena^a ; ^{rsanz.val@quiron.es} ; L. Martí ; -Bonmatí ; ^a ; ^b ; V. Hervá ; s^a ; M. Vega^b ; Á ; . Alberich-Bayarri^a ; G. Garcí ; a-Martí ; ^a ; ^c ; J.M. Carot^d
• 关键词：Cartí ; lago ; Osteoartritis ; Biomarcadores ; Resonancia magné ; tica ; Relajació ; n T1 ; Valores de referencia
• 刊名：Radiolog铆a
• 出版年：2010
• 期刊代码：pca298_00338338
• 类别：med
• 出版时间：May-June 2010
• 卷：52
• 期：3
• 页码：221-227
• 文件大小：549 K

lass="h4">Objectives

To study the viability of longitudinal relaxation time (T1) of patellar cartilage as a biomarker of the degree of degeneration.

lass="h4">Material and methods

We included 15 subjects classified into three groups according to clinical criteria (pain, functional limitation, and duration of symptoms) and imaging criteria as follows: (a) normal (3 men, 2 women; age 30卤14 years), (b) with initial degeneration of the patellar cartilage (3 men, 2 women; age 30卤6 years), or (c) with advanced degeneration (3 men, 2 women; age 57卤10 years). All underwent MRI examination using special echo-gradient sequences to segment the cartilage and calculate the T1 maps. We selected the entire cartilage and the regions of interest classified according to clinical and imaging criteria as normal, initial degeneration, and advanced degeneration. The T1 values of the cartilage were obtained pixel by pixel and were calculated as the mean for the entire cartilage or by subregions (normal, initial, advanced). Differences between groups for the entire cartilage and the regions were analyzed using Student-Newman-Keuls post-hoc ANOVA. Reproducibility was evaluated using the coefficient of variance.

lass="h4">Results

No significant differences in the overall analysis of the entire cartilage were found between the three groups (normal: 1003卤172 ms, initial: 1064卤124 ms, advanced: 1041卤308 ms, p=0.665). However, the analysis by regions revealed significant differences (normal: 908卤53 ms, initial degeneration: 1057卤157 ms, advanced degeneration: 1133卤116 ms, p=0.029). The reproducibility analysis found variations of 1.3%for the overall calculation, 3.7%for the regional calculation, and 8.2%for the acquisition.

lass="h4">Conclusion

In this preliminary study, calculating the T1 of the cartilage enabled regions with different degrees of degeneration to be differentiated.