Synthesis of 5″-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca²⁺-mobilizing agent: The first antagonists modified at the N1-ribose moiety

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• 作者：Natsumi Sakaguchi ; Takashi Kudoh ; Takayoshi Tsuzuki ; Takashi Murayama ; Takashi Sakurai ; Akira Matsuda ; Mitsuhiro Arisawa ; Satoshi Shuto
• 关键词：cADPR ; Nucleotide ; Second messenger ; Ca²⁺-mobilization
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2008
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 July 2008
• 卷：18
• 期：13
• 页码：3814-3818
• 文件大小：322 K

摘要

The 5″-branched cyclic ADP-carbocyclic-ribose derivatives were designed and synthesized. These target compounds were identified as the first antagonists of cADPR without a substituent at the adenine 8-position, and were shown to be stable due to the N1-carbocyclic-ribosyl structure.