Differential contribution of Igepal and C_nTAB micelles on the photophysics of nonsteroidal drug Naproxen

详细信息	查看全文 | 推荐本文 |

• 作者：Soumya Sundar Mati ; Tapas Kumar Mondal ; Sayaree Dhar ; Sayantani Chall ; Subhash Chandra Bhattacharya ; ^{sbjuchem@yahoo.com} ; ^{scbhattacharyya@chemistry.jdvu.ac.in}
• 关键词：Micelles ; Partition ; Quenching ; Anisotropy
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：15 June, 2012
• 卷：92
• 期：Complete
• 页码：122-130
• 文件大小：885 K

摘要

Spectroscopic studies of Naproxen (NP), a nonsteroidal drug have been carried out in well characterized, micellar media of cationic surfactants of a homologous series having general formula C_nTAB (alkyl trimethyl ammonium bromide) and of nonionic surfactants of Igepal (Ig) series (poly(oxyethylene) nonyl phenol). The fluorescence behavior of the drug molecule in C_nTAB micelles has been found to be opposite to that in Igepal micelles. The binding constants during probe micelle binding have been evaluated from relevant fluorescence data. Location and nature of the surrounding medium of the probe in micellar media have been ascertained from fluorescence quenching study. Fluorescence anisotropy parameter has been monitored for exploring the imposed motional restriction of the microenvironment around the probe. Contrasting behavior of the drug molecule has been observed in two different types of micelles. Based on the experimental and theoretical studies, an attempt has been made to explain the different behavior of the probe in different media.