Dose responses in a normoxic polymethacrylic acid gel dosimeter using optimal CT scanning parameters

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• 作者：K.H. Cho^a ; ^b ; S.J. Cho^c ; S. Lee^d ; S.H. Lee^e ; C.K. Min^a ; Y.H. Kim^a ; S.K. Moon^a ; E.S. Kim^a ; A.R. Chang^a ; S.I. Kwon^b ; ^{sikwon@kyonggi.ac.kr}
• 关键词：Normoxic polymethacrylic acid gel ; X-ray CT ; CT scanning parameters
• 刊名：Nuclear Instruments and Methods in Physics Research Section A ; Accelerators ; Spectrometers ; Detectors and Associated Equipment
• 出版年：2012
• 期刊代码：41_01689002
• 类别：ph
• 出版时间：21 May, 2012
• 卷：675
• 期：Complete
• 页码：112-117
• 文件大小：571 K

摘要

The dosimetric characteristics of normoxic polymethacrylic acid gels are investigated using optimal CT scanning parameters and the possibility of their clinical application is also considered. The effects of CT scanning parameters (tube voltage, tube current, scan time, slick thickness, field of view, and reconstruction algorithm) are experimentally investigated to determine the optimal parameters for minimizing the amount of noise in images obtained using normoxic polymethacrylic acid gel. In addition, the dose sensitivity, dose response, accuracy, and reproducibility of the normoxic polymethacrylic acid gel are evaluated.

CT images are obtained using a head phantom that is fabricated for clinical applications. In addition, IMRT treatment planning is performed using a Tomotherapy radiation treatment planning system. A program for analyzing the results is produced using Visual C. A comparison between the treatment planning and the CT images of irradiated gels is performed. The dose sensitivity is found to be 2.41卤0.04 HGy^鈭?. The accuracies of dose evaluation at doses of 2 Gy and 4 Gy are 3.0%and 2.6%, respectively, and their reproducibilities are 2.0%and 2.1%, respectively. In the comparison of gel and Tomotherpay planning, the pass rate of the 纬-index, based on the reference values of a dose error of 3%and a DTA of 3 mm, is 93.7%.