Cognitive outcome after stereotactic amygdalohippocampectomy

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• 作者：Zden臎k Vojt臎ch^a ; ^e ; ^{zdenek.vojtech@homolka.cz} ; Lenka Krá ; mská ; ^b ; Hana Malí ; ková ; ^c ; Kate艡ina Seltenreichová ; ^a ; Tomá ; &scaron ; Prochá ; zka^a ; Miroslav Kalina^a ; Roman Li&scaron ; 膷á ; k^d
• 关键词：AHC ; amygdalo-hippocampal complex ; MTLE ; mesial temporal lobe epilepsy ; MTS ; mesial temporal sclerosis ; SAHE ; stereotactic radiofrequency amygdalohippocampectomy
• 刊名：Seizure
• 出版年：2012
• 期刊代码：281_10591311
• 类别：med
• 出版时间：June, 2012
• 卷：21
• 期：5
• 页码：327-333
• 文件大小：599 K

摘要

Purpose

We sought to determine the neuropsychological outcome after stereotactic radiofrequency amygdalohippocampectomy performed for intractable mesial temporal lobe epilepsy.

Methods

The article describes the cases of 31 patients who were evaluated using the Wechsler Adult Intelligence Scale-Revised and the Wechsler Memory Scale-Revised prior to, and one year after, surgery.

Key findings

Patients showed increases in their mean Full Scale, Verbal and Performance IQ scores of 4, 3 and 4 IQ points respectively (p < .05). 5 (17.2%), 4 (13.8%) and 4 (13.3%) patients improved in their Full-scale, Verbal and Performance IQ respectively. No significant changes were found in memory performance - with a mean increase of 1, 3 and 0 MQ points in Global, Verbal and Visual memory respectively (p < .05). Global memory improved in 3 (10.3%) patients, verbal memory in 1 (3.4%) and 1 patient (3.3%) showed deterioration in visual memory.

Significance

Our results provide evidence for unchanged memory in patients with MTLE after the procedure. No verbal memory deterioration was detected in any of our patients, while improvements were found in intellectual performance. The results suggest that stereotactic radiofrequency amygdalahippocampectomy could be superior to open surgery in terms of its neurocognitive outcomes. A larger randomised trial of these approaches is justified.