- 作者：Ian Dooley ; MRCOphth ; [Author Vitae] ; Fiona D'Arcy ; MRCOphth ; Michael O'Keefe ; FRCOphth ; MD ; mokeefe@materprivate.ie
- 刊名：Journal of Cataract and Refractive Surgery
- 出版年：2012
- 期刊代码：145_08863350
- 类别：med
- 出版时间：June, 2012
- 卷：38
- 期：6
- 页码：1058-1064
- 文件大小：290 K
Purpose
To evaluate the effects of laser in situ keratomileusis (LASIK) and laser-assisted subepithelial keratectomy (LASEK) on dry-eye disease markers including tear osmolarity, Schirmer testing, and the ocular surface disease index (OSDI).Setting
Laser Suite, Mater Private Hospital, Dublin, Ireland.
Design
Prospective controlled cross-sectional observation study.
Methods
In a single center, consecutive eyes that had LASIK or LASEK had dry-eye disease markers assessed preoperatively and 3, 6, and 12 months postoperatively.
Results
In LASIK eyes (n = 50), the mean tear osmolarity was significantly elevated (by 2.8%) at 12 months (P=.009, Student t test). The mean Schirmer test values were not significantly altered postoperatively in either group. The mean OSDI was maximum in LASIK eyes at 3 months (mean follow-up 7.2 months 卤 8.2 [SD]) and in LASEK eyes (n = 35) preoperatively (mean follow-up 9.1聽卤 9.7 months).
Conclusions
There were no significant differences in dry-eye disease markers or tear osmolarity between LASIK and LASEK patients at any stage after surgery up to 1 year. Although tear osmolarity remains one of the highest predictive tests of dry eye, it is complementary with other diagnostic criteria in the context of dry eye after refractive surgery.
Financial Disclosure
No author has a financial or proprietary interest in any material or method mentioned.