Attention Bias to Threat Faces in Children with Bipolar Disorder and Comorbid Lifetime Anxiety Disorders

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• 作者：Melissa A. Brotman ; Brendan A. Rich ; Mariana Schmajuk ; Michelle Reising ; Christopher S. Monk ; Daniel P. Dickstein ; Karin Mogg ; Brendan P. Bradley ; Daniel S. Pine ; Ellen Leibenluft
• 刊名：Biological Psychiatry
• 出版年：2007
• 期刊代码：34_00063223
• 类别：med
• 出版时间：15 March 2007
• 卷：61
• 期：6
• 页码：819-821
• 文件大小：72 K

摘要

Background

Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness.

Methods

Pediatric BD with lifetime anxiety (BD+ANX, n = 20), BD without lifetime anxiety (BD-ANX, n = 11), and controls (n = 14) were administered the visual-probe paradigm, which assesses attention bias to threat faces.

Results

Bipolar disorder +ANX demonstrated a stronger bias toward threat relative to BD-ANX and controls; the latter two did not differ from each other.

Conclusions

Bipolar disorder +ANX showed a bias toward threat while, in two previous studies, anxious children showed a bias away from threat faces. Future studies should compare the pathophysiology of BD with and without a comorbid anxiety disorder and anxiety disorders presenting alone.