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Observations on the microvasculature of bone defects filled with biodegradable nanoparticulate hydroxyapatite
Double staining revealed numerous CD34+ blood vessels but only a few LYVE-1+ lymphatic vessels in BPH and PCa sections. Mean LVD ± SD was distinctly lower (0.55 ± 0.93) in PCa tissue than in tumor periphery (2.45 ± 1.93) and nontumorous (3.16 ± 2.23) tissue (p <0.0001). Maximum LVD was observed in BPH (7.17 ± 3.61), which differed markedly from nontumorous areas of PCa specimens (p <0.001). In contrast to LVD, significantly more blood vessels were found in PCa (116.00 ± 39.25) than in BPH (60.30 ± 19.34) tissue (p <0.001).
LYVE-1 is a specific lymphatic endothelial marker in benign and malignant prostate tissues. It is a useful new marker for the investigation of lymphatics. To our knowledge we report the immunohistochemical visualization and quantification of lymphatic vessels in prostatic tissue for the first time. In contrast to the stimulated angiogenesis of blood vessels in PCa, the destruction of lymphatic vessels occurs rather than lymphangiogenesis.
![]() | An electron Archives of Oral Biology |
![]() Archives of Oral Biology, Volume 15, Issue 12, December 1970, Pages 1117-1122 M. Kukletová Abstract An electron-microscopic study of calf dental pulp revealed vessels with unusual endothelial structure. The lumen of the vessels studied was considerably irregular and the diameter of wider parts ranged about 10–15 μm. The endothelial cells lining the lumen of these vessels were thin. Their cytoplasm contained the usual cytoplasmic organelles, clusters presumed to be beta-granules of glycogen and small pinocytotic vesicles. Both luminal and basal surfaces of the endothelial cells displayed numerous cytoplasmic projections. Some intercellular junctions remained open so that the vessel lumen communicated directly with the surrounding connective tissue. The basal lamina was not fully developed. The vessels described are considered to be lymphatics on the basis of their submicroscopic structure. RésuméUne étude de microscopie électronique de pulpe dentaire de veaux permet de mettre en évidence des vaisseaux présentant une structure endothéliale inhabituelle. La lumière des vaisseaux étudiés est très irrégulière et le diamètre des parties larges varie de 10–15 μ. Les cellules endothéliales, circonscrivant la lumière des vaisseaux, sont minces. Leur cytoplasme contient les organelles cytoplasmiques habituelles, des agglomérats de grains, supposés être des granules de beta glycogène, et de petites vésicules de pinocytose. Les surfaces basales et superficielles des cellules endothéliales présentent de nombreuses projections cytoplasmiques. Certaines jonctions intercellulaires restent ouvertes, de telle sorte que la lumière du vaisseau communique directement avec le tissu conjonctif environnant. La membrane basale n'est pas pleinement développée. Ces vaisseaux sont considérés comme des lymphatiques en se basant sur leur ultrastructure.![]() |
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Observations on the microvasculature of bone defects filled with biodegradable nanoparticulate hydroxyapatite