2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

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• 作者：Mark E. Schnute ; David J. Anderson ; Roger J. Brideau ; Fred L. Ciske ; Sarah A. Collier ; Michele M. Cudahy ; MariJean Eggen ; Michael J. Genin ; Todd A. Hopkins ; Thomas M. Judge ; et al.
• 关键词：Cytomegalovirus ; HCMV ; Varicella-zoster ; VZV ; HSV
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 June 2007
• 卷：17
• 期：12
• 页码：3349-3353
• 文件大小：158 K

摘要

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.