Corrigendum to “Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I” [Bioorg. Med. Chem. Lett. 17 (2007) 2639–2642]

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• 作者：Francesco Epifano ; Massimo Curini ; Salvatore Genovese ; Michelle Blaskovich ; Andrew Hamilton ; Said M. Sebti
• 关键词：Neuroprotective ; Cyclopentenone prostaglandin ; Apoptosis ; Manganese ion ; Perkinson’ ; s disease
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 October 2007
• 卷：17
• 期：19
• 页码：5492
• 文件大小：69 K

摘要

The synthesis and evaluation for anti- and proapoptotic properties of cyclopentenone prostaglandin analogs are described. Novel J-type analogs of NEPP11 with a cross-conjugated cyclopentadienone moiety and a lipophilic ω-side chain suppressed manganese ion-induced apoptosis of PC12 cells at comparable levels to NEPP11, while monoenone derivatives were inactive. The proapoptotic activities of J-type analogs were much lower than that of NEPP11. Natural 15-deoxy-Δ^12,14-PGJ₂ and Δ⁷-PGA₁ methyl ester were highly toxic, inducing apoptosis at lower concentrations.