Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis
- 作者：Bettina Kuenz ; Andreas Lutterotti ; Michael Khalil ; Rainer Ehling ; Claudia Gneiss ; Florian Deisenhammer ; Markus Reindl and Thomas Berger
- 关键词：Multiple sclerosis ; Soluble platelet endothelial cell adhesion molecule-1(sPECAM-1) ; Soluble E-selectin (sE-selectin) ; Soluble P-selectin (sP-selectin) ; Plasma
- 刊名：Journal of Neuroimmunology
- 出版年：2005
- 期刊代码：32_01655728
- 类别：neu
- 出版时间：2005
- 卷：167
- 期：1-2
- 页码：143-149
- 文件大小：335 K
摘要
Adhesion molecule mediated leukocyte migration into the central nervous system is considered to be a critical step in the pathogenesis of multiple sclerosis (MS). We measured plasma levels of the soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin in 166 MS patients and in 36 healthy blood donors with ELISA. sPECAM-1, sP-selectin and sE-selectin plasma concentrations showed a significant increase in the relapsing-remitting disease course of MS and were elevated during relapse. These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease.