Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells

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• 作者：Tamami Yasukagawa ; Yuki Niwa ; Siro Simizu ; Kazuo Umezawa ; ^{umezawa@applc.keio.ac.jp}
• 关键词：Potassium channel ; Ovarian cancer ; Platelet-derived growth factor ; Glybenclamide ; Trafficking ; Tumor invasion
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：21 May, 2012
• 卷：586
• 期：10
• 页码：1504-1509
• 文件大小：557 K

摘要

It has been demonstrated that potassium channels (K⁺ channels) play significant roles in some malignant phenotypes. Here, we provide the first evidence that treatment with glybenclamide, an ATP-sensitive K⁺ channel blocker, inhibited cell migration in an ovarian clear cell carcinoma cell line, ES-2. Treatment with glybenclamide or knockdown by siRNA targeted against K⁺ channel subunits demonstrated the suppression of ovarian cancer cell invasion, which occurred via inhibition of PDGF-AA secretion. Therefore, our findings suggest that K⁺ channel blockers may be useful chemotherapeutic drugs for blocking the invasiveness of ovarian cancers.