No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study
- 作者：Bharat Thyagarajan ; Kristin E. Anderson ; Aaron R. Folsom ; David R. Jacobs ; Jr. ; Charles F. Lynch ; Archana Bargaje ; Waseem Khaliq and Myron D. Gross
- 关键词：Postmenopausal breast cancer ; Polymorphisms ; DNA repair ; Base excision repair ; Double strand DNA repair ; Nested case control study ; IWHS ; INVADER assay ; Paraffin embedded tissue ; Genotype ; Arg399Gln ; BMI ; Risk factors ; Statistical analysis
- 刊名：Cancer Detection and Prevention
- 出版年：2006
- 期刊代码：163_0361090x
- 类别：bio
- 出版时间：2006
- 卷：30
- 期：4
- 页码：313-321
- 文件大小：237 K
摘要
Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms—PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95%CI: 0.78–1.88); Arg399Gln (OR = 1.20, 95%CI: 0.80–1.79); XRCC3: Thr241Met (OR = 1.04, 95%CI: 0.76–1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.