Tobacco smoke-induced left ventricular remodelling is not associated with metalloproteinase-2 or -9 activation

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• 作者：Edson Castardeli ; Daniella R. Duarte ; Marcos F. Minicucci ; Paula S. Azevedo ; Beatriz B. Matsubara ; Luiz S. Matsubara ; Á ; lvaro O. Campana ; Sergio A.R. Paiva ; Leonardo A.M. Zornoff
• 关键词：Ventricular function ; Cardiac remodelling ; Ventricular dilatation
• 刊名：European Journal of Heart Failure
• 出版年：2007
• 期刊代码：90_13889842
• 类别：med
• 出版时间：November 2007
• 卷：9
• 期：11
• 页码：1081-1085
• 文件大小：145 K

摘要

To investigate the role of MMP-2 and MMP-9 in cardiac remodelling induced by tobacco smoke exposure in rats.

Methods

Rats were allocated into two groups: C (n = 9): control animals; ETS (n = 9): exposed to tobacco smoke. After 4months, the animals underwent echocardiography, morphometric study and determination of MMP-2 and MMP-9 activity.

Results

ETS rats had larger diastolic (C = 15.6 ± 1.2 mm/kg, ETS = 18.0 ± 0.9 mm/kg; p < 0.001) and systolic (C = 7.3 ± 1.2 mm/kg, ETS = 9.2 ± 0.9 mm/kg; p = 0.001) ventricular diameters adjusted for body weight. Fractional shortening (C = 53 ± 4.8%, ETS = 48 ± 3.3%; p = 0.031) and ejection fraction (C = 0.89 ± 0.03, ETS = 0.86 ± 0.02; p = 0.030) were smaller in the ETS group. Myocyte cross-sectional area (C = 245 ± 8 μm², ETS = 253 ± 8 μm²; p = 0.028) was higher in ETS rats. There were no differences in MMP-2 (C = 50 ± 14%; ETS = 43 ± 11%, p = 0.228) or MMP-9 (C = 0.36 ± 0.3%; ETS = 0.62 ± 0.3%, p = 0.630) activity between the groups.

Conclusion

MMP-2 and MMP-9 did not participate in the remodelling process induced by tobacco smoke exposure.