• 作者：M.C. Serrano Martí ; n ; ^{maria.serrano@sc.juntaex.es} ; I. Pé ; rez Sá ; nchez ; R. Rodrí ; guez Ló ; pez ; J.C. Expó ; sito Beltrá ; n ; J.A. Gonzá ; lez Lucio ; M.M. Á ; lvarez Dí ; az
• 关键词：Vacuna ; Rotavirus ; Diarrea ; Prevenció ; n ; Epidemiologí ; a
• 刊名：Vacunas
• 出版年：2008
• 期刊代码：pca365_15769887
• 类别：med
• 出版时间：December 2008
• 卷：9
• 期：4
• 页码：151-155
• 文件大小：146 K

Objective

We calculated the efficiency of routine rotavirus vaccination in Extremadura.

Material and methods

The Microbiological Information System (SIM) was used to calculate the incidence of rotavirus infection between 2003 and 2005, in order to estimate social and health costs. The cost of vaccination with two doses before 24 months of age of 95%of the cohort of neonates was obtained.

The cost was calculated by cases avoided in 10 years with an estimated effectiveness of the vaccine of 80%.

A cost-benefit analysis was made to evaluate the efficiency of the rotavirus vaccination programme.

Results

The mean annual incidence was 49.62 cases 脳 10⁵ inhabitants.

The health cost of a case was 1381.51 鈧? the mean annual cost of infection was 726,574.94 鈧? In ten years, an estimated 2.453 cases would be avoided, meaning a saving of 3,343,880.54 鈧?(with an estimated vaccine effectiveness of 80%).

The total annual cost of the program would be 1,972,669.62 鈧? Vaccination would be necessary for 10 years to cover the population, with a cost of 19,726.696.20 鈧? Avoiding a case in 10 years would cost 8,041.87 鈧? The 10 -year cost/benefit ratio would be 5.82.

Conclusion

Rotavirus vaccination would reduce the incidence of mild/moderate cases of gastroenteritis and hospitalizations. Routine rotavirus vaccination would not be efficient in a 10-year period.