Foxp3⁺CD25^high CD4⁺ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity

详细信息	查看全文 | 推荐本文 |

• 作者：F.F. de Araú ; jo^a ; R. Corrê ; a-Oliveira^a ; ^b ; M.O.C. Rocha^c ; ^d ; A.T. Chaves^a ; J.A. Fiuza^a ; ^e ; R.C.G. Fares^a ; K.S. Ferreira^a ; ^f ; M.C.P. Nunes^d ; T.S. Keesen^g ; M.P.S. Damasio^f ; A. Teixeira-Carvalho^h ; J.A.S. Gomes^a ; ^c ; ^f ; ^{estanislau.juliana@gmail.com} ; ^{juliana@icb.ufmg.br}
• 关键词：CARD ; patient with cardiac clinical form of the disease ; IND ; patient with indeterminate clinical form of the disease ; SEA ; Schistosoma mansoni soluble egg antigens ; SWAP ; Schistosoma mansoni soluble adult worm antigen preparation ; PBMC ; peripheral blood
• 刊名：Immunobiology
• 出版年：2012
• 期刊代码：3_01712985
• 类别：imm
• 出版时间：August, 2012
• 卷：217
• 期：8
• 页码：768-777
• 文件大小：1051 K

摘要

Immunoregulatory mechanisms are important to control the intense immune activity induced in Chagas disease. We evaluated the phenotypic profile and the mechanisms by which Treg cells function in patients with the indeterminate (IND) and cardiac (CARD) clinical forms of Chagas disease. The frequency of Foxp3⁺CD25^high CD4⁺-T cells is augmented and correlated with the maintenance of a better cardiac function in IND. Treg cells from IND present suppressive activity, although the mechanism is not IL-10 or CTLA-4 dependent and are able to produce augmented levels of IL-17, IL-10 and granzyme B being its frequency correlated with percentage of Annexin V⁺ CD4⁺-cells. In contrast, CARD presents higher frequency of IL-6⁺, IFN-gamma⁺, TNF-alpha⁺ and CTLA-4⁺ Treg-cells than IND. Thus, our data suggest that Treg cells have an important role in controlling the exacerbated immune response and morbidity in Trypanosoma cruzi infection, probably modulating the cytokine environment and/or killing effector cells.