- 作者：Wojciech Dabrowski ; MD ; PhD鈦?/sup> ; w.dabrowski5@yahoo.com ; Ziemowit Rzecki ; MD ; PhD鈦?/sup> ; Marek Czajkowski ; MD ; PhD&dagger ; ; Jacek Pilat ; MD ; PhD&Dagger ; ; Piotr Wacinski ; MD ; PhD§ ; ; Edyta Kotlinska ; MD ; PhD鈦?/sup> ; Ma艂gorzata Sztanke ; MD ; PhD鈭?/sup> ; Krzysztof Sztanke ; PhD鈭?/sup> ; Krzysztof Stazka ; MD鈭?/sup> ; Kazimierz Pasternak ; MD ; PhD鈭?/sup>
- 关键词：magnesium ; sevoflurane ; isoflurane ; matrix metalloproteinase-9 ; glial fibrillary acidic protein ; coronary artery bypass graft surgery ; extracorporeal circulation
- 刊名：Journal of Cardiothoracic and Vascular Anesthesia
- 出版年：2012
- 期刊代码：163_10530770
- 类别：med
- 出版时间：June, 2012
- 卷：26
- 期：3
- 页码：395-402
- 文件大小：393 K
Objectives
Neuropsychological disorders are some of the most common complications of coronary artery bypass graft (CABG) surgery. The early diagnosis of postoperative brain damage is difficult and mainly based on the observation of specific brain injury markers. The aim of this study was to analyze the effects of volatile anesthesia (VA) on plasma total and ionized arteriovenous magnesium concentrations in the brain circulation (a-vtMg and a-viMg), plasma matrix metalloproteinase-9 (MMP-9), and glial fibrillary acidic protein (GFAP) in adult patients undergoing CABG surgery.Design
An observational study.
Setting
The Department of Cardiac Surgery in a Medical University Hospital.
Patients and Methods
Studied parameters were measured during surgery and in the early postoperative period. Patients were assigned to 3 groups: group O, patients who did not receive VA; group ISO, patients who received isoflurane; and group SEV, patients who received sevoflurane.
Results
Ninety-two patients were examined. CABG surgery increased MMP-9 and GFAP. The highest MMP-9, GFAP, and the most dramatic disorders in a-vtMg and a-viMg were noted in group O.
Conclusions
Cardiac surgery increased plasma MMP-9 and GFAP concentrations. Changes in MMP-9, GFAP, and arteriovenous tMg and iMg were significantly higher in group O. Volatile anesthetics, such as ISO or SEV, reduced plasma MMP-9, GFAP concentrations, and disturbances in a-vtMg and a-viMg.