Combined treatment using peripheral nerve graft and FGF-1: Changes to the glial environment and differential macrophage reaction in a complete transected spinal cord
- 作者：Meng-Jen Lee ; Ching JungChen ; Chu-Hsun Cheng ; Wen-Cheng Huang ; Huai-Sheng Kuo ; Jau-Ching Wu ; May J. Tsai ; Ming-Chao Huang ; Wen-Chi Chang ; Henrich Cheng
- 关键词：FGF-1 ; Back-degeneration ; Astrocytic scarring ; Reactive gliosis ; Macrophage ; Ketatan sulphate proteoglycan (KSPG)
- 刊名：Neuroscience Letters
- 出版年：2008
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：15 March 2008
- 卷：433
- 期：3
- 页码：163-169
- 文件大小：3063 K
摘要
We used a complete spinal cord transection model in which the T8 spinal segment was removed to study the effect of combined treatment of peripheral nerve graft and application of FGF-1 on the glial environment. The combined treatment resulted in reduced astrocytic glial scarring, reactive macrophage gliosis, and inhibitory proteoglycan in the back-degenerated white matter tract. While the macrophage activities in the back-degenerative tract were down-regulated, those in the grafted peripheral nerves and in the distal Wallerian degenerative tracts were not. We concluded that the combined treatment changed the glial environment in the back-degenerative tract, and differentially regulated the macrophage activities in the system, in favor of CNS regeneration.