Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies

详细信息	查看全文 | 推荐本文 |

• 作者：Ze-Mu Wang^a ; ¹ ; Zhen-Lin Nie^b ; ¹ ; Bo Zhou^c ; Xiao-Qing Lian^a ; Huan Zhao^a ; Wei Gao^a ; Yong-Sheng Wang^a ; En-Zhi Jia^a ; Lian-Sheng Wang^a ; Zhi-Jian Yang^a ; ^{zhijianyangnj@yahoo.com.cn}
• 关键词：Flavonols ; Coronary heart disease ; Meta-analysis
• 刊名：Atherosclerosis
• 出版年：2012
• 期刊代码：28_00219150
• 类别：med
• 出版时间：May, 2012
• 卷：222
• 期：1
• 页码：270-273
• 文件大小：199 K

摘要

Objective

Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies.

Methods

We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model.

Results

A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95%CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20 mg/day, summary RR: 0.96; 95%CI: 0.90, 1.03).

Conclusions

Our results do not support a protective role of flavonols intake against CHD.