Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men

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• 作者：Hironori Imano ; Shinichi Sato ; Akihiko Kitamura ; Masahiko Kiyama ; Tetsuya Ohira ; Takashi Shimamoto ; Hiroyasu Iso
• 关键词：Leukocyte count ; Acute myocardial infarction ; Stroke ; Smoking ; Prospective studies ; Incidence ; Men
• 刊名：Atherosclerosis
• 出版年：2007
• 期刊代码：28_00219150
• 类别：med
• 出版时间：November 2007
• 卷：195
• 期：1
• 页码：147-152
• 文件大小：98 K

摘要

Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking.

Methods

The subjects were 4492 male employees aged 40–59 years who worked for nine companies in Osaka.

Results

After 9-year follow-up, 40 acute myocardial infarction and 26 ischemic stroke events occurred. Age-adjusted relative risk of acute myocardial infarction in the highest versus lowest quartiles of leukocyte count was 6.0 (95%CI, 1.8–20.5, P for trend <0.001) and the multivariable relative risk adjusted for smoking and other conventional cardiovascular risk factors was 3.7 (1.0–13.4, P for trend = 0.01). The association between leukocyte count and the risk of acute myocardial infarction was also observed among both current smokers and nonsmokers. The positive association between leukocyte count and the risk of ischemic stroke was weak and did not reach statistical significance.

Conclusions

Leukocyte count is a predictor of acute myocardial infarction among Japanese middle-aged men, both in smokers and nonsmokers.