A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells
- 作者：Masakazu Abe ; Tsuyoshi Sugiura ; Miho Takahashi ; Kotaro Ishii ; Miyuki Shimoda ; Kanemitsu Shirasuna
- 关键词：CD82/KAI-1 ; E-cadherin ; β ; -Catenin ; Cancer invasion ; Cell adhesion
- 刊名：Cancer Letters
- 出版年：2008
- 期刊代码：44_03043835
- 类别：med
- 出版时间：8 August 2008
- 卷：266
- 期：2
- 页码：163-170
- 文件大小：737 K
摘要
In this study, we analyzed the effect of the metastasis suppressor CD82/KAI-1, a member of the tetraspanin superfamily, on intercellular adhesion on cancer cells. The newly established invasion assay and the cell aggregation assay revealed that CD82 strengthens E-cadherin-mediated intercellular adhesion. Interestingly, ectopic expression of CD82 stabilized E-cadherin/β-catenin complex formation. Furthermore, CD82 reduced tyrosine phosphorylation of β-catenin on HGF stimulation. Taken together, CD82 may stabilize or strengthen E-cadherin-dependent intercellular adhesion by regulating β-catenin-mediated signal transduction on cancer cells, and consequently, prevent cancer cells from seceding from the primary tumor site.