Basal ganglia germinoma: Diagnostic value of MR spectroscopy and 11C-methionine positron emission tomography
- 作者：Yuji Fujii ; Yoshiaki Saito ; Toshihide Ogawa ; Shinya Fujii ; Hideki Kamitani ; Shinji Kondo ; Yasushi Horie ; Masami Togawa ; Michio Senda ; Yoshihiro Maegaki ; Kousaku Ohno
- 关键词：Germinoma ; Basal ganglia ; Childhood ; Magnetic resonance spectroscopy ; 11C-methionine positron emission tomography ; Basal ganglia atrophy
- 刊名：Journal of the Neurological Sciences
- 出版年：2008
- 期刊代码：178_0022510x
- 类别：med
- 出版时间：15 July 2008
- 卷：270
- 期：1-2
- 页码：189-193
- 文件大小：1772 K
摘要
We herein report a 12-year-old girl with a basal ganglia germinoma who presented with right-sided hemiparesis after a minor head trauma. Magnetic resonance (MR) imaging revealed a minimally enhanced lesion involving the left putamen, thalamus, and corona radiata. The lesion showed low-signal intensity on T1-, and high intensity on T2- and diffusion-weighted imaging. The MR signal in the adjacent globus pallidum was also low on T2-weighted imaging. MR spectroscopy on the lesion showed a large lactate/lipid/macromolecule peak with a decreased NAA/Cr ratio, but no increase in the Cho/Cr ratio. However, posttraumatic infarction at the territory of lateral lenticulostriate artery was ruled out 1 month later. This was based on progression of the hemiparesis and neuroimaging results, including an increased Cho/Cr ratio and weak uptake on 11C-methionine positron emission tomography of the basal ganglia lesion. Stereotaxic brain biopsy confirmed the diagnosis of germinoma.