Longitudinal ¹H MRS changes in mild cognitive impairment and Alzheimer's disease

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• 作者：Kejal Kantarci ; Stephen D. Weig ; Ronald C. Petersen ; Bradley F. Boeve ; David S. Knopman ; Jeffrey Gunter ; Denise Reyes ; Maria Shiung ; Peter C. O’ ; Brien ; Glenn E. Smith ; Robert J. Ivnik ; Eric G.
• 关键词：¹H MR spectroscopy ; ¹H MRS ; Imaging ; Alzheimer's disease ; Mild cognitive impairment ; Serial ; Longitudinal ; N-Acetylaspartate ; Choline
• 刊名：Neurobiology of Aging
• 出版年：2007
• 期刊代码：202_01974580
• 类别：med
• 出版时间：September 2007
• 卷：28
• 期：9
• 页码：1330-1339
• 文件大小：248 K

摘要

Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in ¹H MR spectroscopy (¹H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal ¹H MRS metabolite changes in patients with MCI, and AD, and to compare ¹H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in ¹H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that ¹H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.