New sesquiterpenes from the roots of Coriaria nepalensis

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• 作者：Fen Zhao ; Yun-Bao Liu ; Shuang-Gang Ma ; Jing Qu ; Shi-Shan Yu ; ^{yushishan@imm.ac.cn} ; Zhen-Feng Fang ; Li Li ; Yi-Kang Si ; Jian-Jun Zhang
• 关键词：Coriaria nepalensis ; Sesquiterpene ; Anti-convulsant activity
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：5 August, 2012
• 卷：68
• 期：31
• 页码：6204-6210
• 文件大小：597 K

摘要

Six new trace sesquiterpenes, corialactones A-D (1-4), coriantone (5), corianol (6), together with nine known ones (7-15), were isolated from the roots of Coriaria nepalensis. The structures of 1-6 were elucidated through a combination of extensive NMR spectroscopic analysis, HRESIMS, CD, Rh₂(OCOCF₃)₄-induced CD, Snatzke's method, and X-ray crystallography. Compounds 2-4, and 6 possess characteristic structural units compared with the previously reported sesquiterpenes from this family. In聽vivo system, compounds 5, 6 and 10 showed anti-convulsant activity by 20%, 60%, and 20%at the dose of 5聽mg/kg, respectively.