Mekongenines A and B, two new alkaloids from Bousigonia mekongensis

详细信息	查看全文 | 推荐本文 |

• 作者：Yanhui Fu^a ; ^b ; Hongping He^a ; Yingtong Di^a ; Shunlin Li^a ; Yu Zhang^a ; ^{zhangyu@mail.kib.ac.cn} ; Xiaojiang Hao^a ; ^{haoxj@mail.kib.ac.cn}
• 关键词：Bousigonia mekongensis ; Alkaloids ; Mekongenine A ; Mekongenine B
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：11 July, 2012
• 卷：53
• 期：28
• 页码：3642-3646
• 文件大小：739 K

摘要

Mekongenine A (1) possessing an unprecedented structure constituted from the union of a rare 2,7-seco eburnamine half and an aspidospermine alkaloid, together with a new bisindole alkaloid, mekongenine B (2), consisting of an eburnamine-aspidospermine type skeleton, was isolated from Bousigonia mekongensis. Their structures were elucidated by means of spectroscopic methods and those of 2 were further confirmed by X-ray diffraction. The absolute configurations of 1 and 2 were determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Mekongenines A (1) and B (2) exhibited cell growth inhibitory activities against various human cancer cell lines.