Autoimmune manifestations in acquired idiopathic splenic atrophy: A puzzling association
- 作者：P. Coppo ; D. Saadoun ; B. Varet
- 关键词：Splenic atrophy ; Thrombocytosis ; Autoimmunity ; Systemic lupus erythematosus ; Sjö ; gren's syndrome
- 刊名：European Journal of Internal Medicine
- 出版年：2006
- 期刊代码：91_09536205
- 类别：med
- 出版时间：December 2006
- 卷：17
- 期：8
- 页码：580-582
- 文件大小：278 K
摘要
Splenic atrophy is an uncommon diagnosis associated with celiac sprue or other well-characterized connective tissue diseases, drepanocytosis, or amyloidosis. We report two patients with splenic atrophy revealed by thrombocytosis. Both patients had anti-nuclear antibodies. Patient 1 also had a grade III Chisholm lymphocytic sialadenitis with a rheumatoid factor, anti-extractable nuclear antibodies, and a polyclonal hypergammaglobulinemia consistent with the diagnosis of Sjögren's syndrome. Patient 2 displayed a previous history of idiopathic pericarditis. An anti-pneumococcal vaccination was given to both patients and neither experienced infectious complications. Splenic atrophy should be suspected in patients with thrombocytosis of unexplained origin and a blood smear consistent with asplenia. Such patients must be checked for clinical and biological symptoms of autoimmune disorders.