• 作者：J.I. Rojas^a ; ^{juan.rojas@hospitalitaliano.org.ar} ; L. Patrucco^a ; C. Besada^b ; L. Bengolea^b ; E. Cristiano^a
• 关键词：Sí ; ndromes desmielinizantes aislados ; Atrofia cerebral ; SIENAX ; Esclerosis mú ; ltiple
• 刊名：Neurolog铆a
• 出版年：2010
• 期刊代码：pca262_02134853
• 类别：med
• 出版时间：September 2010
• 卷：25
• 期：7
• 页码：430-434
• 文件大小：258 K

Introduction

Previous reports have shown that brain atrophy appears early in the course of multiple sclerosis (MS). The aim of the present study was to evaluate whether brain atrophy already exists in clinically isolated syndrome (CIS) by comparing with a control sample.

Methods

Patients with CIS were included prospectively from June 2008 to June 2009. A control group of healthy persons, matched by age and gender with CIS, was also included during the same period of time. An automated analysis tool, SIENAX, was used to obtain total brain volume (TBV), gray matter volume (GMV) and white matter volume (WMV). Mann-Whitney U test was used to analyze the data.

Results

Twenty CIS patients and 30 healthy controls were included (8 vs. 17 females, p = 0.11). Mean age for CIS was 35 卤 6 years vs. 34.4 卤 5 in controls (p = 0.61). Mean EDSS in CIS was 1.1 卤 0.5. Eighteen patients with CIS (90%) had abnormal baseline MRI. The TBV in CIS was 1.6 渭l 卤 0.22 渭l 脳 10⁶ vs.1.65 卤 0.15 脳 10⁶ in controls (p = 0.005), the GMV in CIS was 0.58 卤 0.05 脳 10⁶ vs. 0.67 卤 0.03 脳 10⁶ in controls (p 鈮?0.001) and the WMV in CIS was 1 卤 0.1 脳 10⁶ vs. 1.12 卤 0.02 脳 10⁶ in controls (p = 0.03).

Conclusions

This is the first study dealing with brain atrophy in a CIS sample from Latin America in which brain atrophy, mainly grey matter atrophy, was shown in early stages of the disease compared with healthy individuals.