Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy

详细信息	查看全文 | 推荐本文 |

• 作者：Tavani ; Alessandra ; Bertuzzi ; Michaela ; Gallus ; Silvano ; Negri ; Eva ; La Vecchia ; Carlo
• 刊名：Journal of Clinical Epidemiology
• 出版年：2005
• 期刊代码：148_08954356
• 类别：med
• 出版时间：July, 2005
• 卷：58
• 期：7
• 页码：747-750
• 文件大小：159 K

摘要

Background

Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy.

Methods

We used a combined dataset from three hospital-based case–control studies including a total of 479 women aged ≥45 years with a first episode of nonfatal AMI and 822 hospital controls.

Results

Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95%confidence interval, 0.9–2.2); no consistent pattern of risk was observed according to duration or time since last use.

Conclusions

HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.