A simple method for the alkaline hydrolysis of esters

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• 作者：Vassiliki Theodorou ; Konstantinos Skobridis ; Andreas G. Tzakos ; Valentine Ragoussis
• 关键词：Saponification of esters ; Mechanism ; Non-aqueous conditions ; Methanolysis ; Selective enrichment of COOH ; Carboxylic acids ; Alcohols
• 刊名：Tetrahedron Letters
• 出版年：2007
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：12 November 2007
• 卷：48
• 期：46
• 页码：8230-8233
• 文件大小：110 K

摘要

A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed.