Acinic cell carcinoma of the parotid gland with skull base invasion: Case study, managed by exclusive external 3D radiation therapy

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• 作者：G. Buiret^a ; ^b ; ^{guillaume.buiret@laposte.net} ; P. Cé ; ruse^c ; A. Ramade^c ; C. Carrie^a ; P. Pommier^a
• 关键词：Salivary gland neoplasm ; Skull base neoplasm ; Radiation therapy
• 刊名：European Annals of Otorhinolaryngology ; Head and Neck Diseases
• 出版年：2012
• 期刊代码：pca156_18797296
• 类别：med
• 出版时间：April, 2012
• 卷：129
• 期：2
• 页码：111-114
• 文件大小：612 K

摘要

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Summary

Objective

To review treatment options in a rare type of parotid tumor, in a clinical case study.

Case study

A 62-year-old woman presenting with recurrence of acinic cell carcinoma of the parotid gland with invasion of the skull base was treated by external 3D conformational radiation, having refused large-scale exeresis. Sixty-six Gy (70 Gy equivalent) were delivered in 2007. Clinical and paraclinical follow-up found regular tumor volume regression over a 2.5-year period without side-effects of radiation.

Discussion

There are no specific data on the efficacy of external radiation therapy in acinic cell carcinoma; reports on exclusive radiation treatment of salivary gland cancer include different histological types. Exclusive radiation treatment should be at least 66-70 Gy, preferably by neutron- or hadrontherapy.

Conclusion

Management of acinic cell carcinoma of the parotid is surgical with possible secondary radiation therapy; exclusive external radiation therapy is, however, an option in case of contra-indication for surgery or patient refusal.