A preliminary quantitative analysis of REM sleep chin EMG in Parkinson鈥檚 disease with or without REM sleep behavior disorder

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• 作者：Raffaele Ferri^a ; ^{rferri@oasi.en.it} ; ^{raffaele.ferri@tiscali.it} ; Stephany Fulda^a ; Filomena I.I. Cosentino^a ; Fabio Pizza^b ; Giuseppe Plazzi^b
• 关键词：REM sleep behavior disorder ; Parkinson&rsquo ; s disease ; REM sleep Atonia Index ; Chin EMG analysis ; REM sleep without atonia ; Synucleinopathies
• 刊名：Sleep Medicine
• 出版年：2012
• 期刊代码：241_13899457
• 类别：med
• 出版时间：June, 2012
• 卷：13
• 期：6
• 页码：707-713
• 文件大小：350 K

摘要

Objectives

To compare REM sleep chin EMG quantitative features between Parkinson鈥檚 disease (PD) patients with or without REM sleep behavior disorder (RBD).

Subjects and methods

Twenty-seven consecutive PD patients (mean age 67.9 years) and 19 normal controls (mean age 67.5 years) were enrolled. Detailed clinical, laboratory, and polysomnographic studies were obtained in all participants and characteristics of chin electromyographic amplitude during rapid eye movements sleep were analyzed by means of an automatic quantitative approach (Atonia Index).

Results

Sixteen of the 27 patients were affected by RBD. An Atonia Index below 0.90 showed high sensitivity (0.938) and specificity (0.909) for the diagnosis of RBD within the group of PD patients.

Conclusion

This study recommends the Atonia Index as an objective measure to support and aid the diagnosis of RBD in PD.