Normalizing renal reducing ability prevents adriamycin-induced proteinuria
- 作者：Takaaki Oteki ; Sohji Nagase ; Hidekatsu Yokoyama ; Hiroaki Ohya ; Takao Akatsuka ; Mika Tada ; Atsushi Ueda ; Aki Hirayama and Akio Koyama
- 关键词：Adriamycin nephropathy ; Reactive oxygen species ; Antioxidants ; Renal reducing ability ; Electron paramagnetic resonance
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2005
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：2005
- 卷：337
- 期：1
- 页码：48-51
- 文件大小：193 K
摘要
Reactive oxygen species play an important role in adriamycin (ADR) nephropathy. We showed by in vivo electron paramagnetic resonance (EPR) that renal reducing ability (RRA) declined on the 7th day after ADR administration. Proteinuria appeared after the decline in RRA. The aim of this study was to prove by in vivo EPR whether the decline in RRA is altered by scavengers such as dimethyl sulfoxide (DMSO) and dimethylthiourea (DMTU) and that it is this change which is responsible for the proteinuria in ADR nephropathy. By showing that DMSO and DMTU ameliorate the RRA, we demonstrate that the decline in RRA is related to ADR-induced proteinuria.