Novel and efficient protocol for the syntheses of N-1 substituted thiohydantoin and a bicyclothiohydantoin under solvent-free conditions

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• 作者：Vinod Kumar^a ; ^{vkpal77@yahoo.co.in} ; Hemlata Rana^a ; Ravish Sankolli^b ; M.P. Kaushik^a
• 关键词：Thiohydantoin ; Methyl N-cyano-N-alkyl/arylaminoacetate ; Bicyclothiohydantoin and bis-thiohydantoin ; Diethylthiophosphate ; Solvent-free conditions
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：9 May, 2012
• 卷：53
• 期：19
• 页码：2377-2379
• 文件大小：1386 K

摘要

A novel approach for the synthesis of N-1 substituted thiohydantoin has been developed to give quantitative yields of the desired products. The efficient synthesis of bis-thiohydantoin derivative and bicyclothiohydantoin has extended scope and applicability of present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. All the products were characterized by spectroscopic techniques and elemental analysis, and finally the structure of representative compound was also confirmed by X-ray crystallography.