Aqueous ring opening of N-tosylaziridine with aniline derivatives

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• 作者：Mengping Zhu ; Bahram Moasser ; ^{bm276@georgetown.edu}
• 关键词：Catalysis ; Aziridine ; Aqueous ; Ring opening ; On water
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2 May, 2012
• 卷：53
• 期：18
• 页码：2288-2291
• 文件大小：268 K

摘要

A series of N-(p-X-phenyl)-N鈥?(p-toluenesulfonyl)1,2-ethylenediamines compounds, TsN(H)CH₂CH₂N(H)PhX, were synthesized by the uncatalyzed ring opening reaction of N-tosylaziridine with p-X-aniline derivatives in pure water at 50 掳C. No solvolysis product was observed and the only side product was that of a subsequent ring opening reactions of N-tosylaziridine with the product anilines leading to substituted diethylenetriamines, XPhN(CH₂CH₂NTs)₂.