Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans

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• 作者：Setsu Nakatani-Enomoto^a ; ^{setsu-tky@umin.ac.jp} ; Ritstuko Hanajima^b ; Masashi Hamada^b ; Yasuo Terao^b ; Hideyuki Matsumoto^b ; Yuichiro Shirota^b ; Shingo Okabe^b ; Masaki Hirose^a ; Koichiro Nakamura^a ; Toshiaki Furubayashi^a ; ^c ; Shunsuke Kobayashi^a ; Hitoshi Mochizuki^a ; Hiroyuki Enomoto^a ; Yoshikazu Ugawa^a ; ^d
• 关键词：Quadripulse transcranial magnetic stimulation (QPS) ; Somatosensory evoked potential ; Long-term potentiation ; Long-term depression ; Homotopic effect ; Heterotopic effect
• 刊名：Clinical Neurophysiology
• 出版年：2012
• 期刊代码：61_13882457
• 类别：med
• 出版时间：July, 2012
• 卷：123
• 期：7
• 页码：1415-1421
• 文件大小：588 K

摘要

Objective

Quadripulse transcranial magnetic stimulation (QPS) is a newly designed patterned repetitive transcranial magnetic stimulation (TMS). Previous studies of QPS showed bidirectional effects on the primary motor cortex (M1), which depended on its inter-stimulus interval (ISI): motor evoked potentials (MEPs) were potentiated at short ISIs and depressed at long ISIs (homotopic effects). These physiological characters were compatible with synaptic plasticity. In this research, we studied effects of QPS on the primary sensory cortex (S1).

Methods

One burst consisted of four monophasic TMS pulses at an intensity of 90%active motor threshold. The ISI of four pulses was set at 5 ms (QPS-5) or at 50 ms (QPS-50). Same bursts were given every 5 s for 30 min. QPS-5 and QPS-50 were performed over three areas (M1, S1 and dorsal premotor cortex (dPMC)). One sham stimulation session was also performed. Excitability changes of S1 were evaluated by timeline of somatosensory evoked potentials (SEPs).

Results

QPS-5 over M1 or dPMC enhanced the P25-N33 component of SEP, and QPS-50 over M1 depressed it. By contrast, QPSs over S1 had no effects on SEPs.

Conclusions

QPSs over motor cortices modulated the S1 cortical excitability (heterotopic effects). Mutual connections between dPMC or M1 and S1 might be responsible for these modulations.

Significance

QPSs induced heterotopic LTP or LTD-like cortical excitability changes.