Synthesis and antimicrobial activities of structurally novel S,S鈥?bis(heterosubstituted) disulfides

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• 作者：Praveen Ramaraju^a ; Danielle Gergeres^a ; Edward Turos^a ; ^{eturos@usf.edu} ; ^{eturos@shell.cas.usf.edu} ; Sonja Dickey^b ; Daniel V. Lim^b ; John Thomas^c ; Burt Anderson^c
• 关键词：Disulfides ; MRSA ; Francisella tularensis ; Candida albicans ; Bacteriostatic
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 June, 2012
• 卷：22
• 期：11
• 页码：3623-3631
• 文件大小：1097 K

摘要

The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S鈥?bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillin-resistant S. aureus and F. tularensis.