Cs₂CO₃ in pyrrolidinone promoted hydration of functionalized (hetero)aryl nitriles under metal-free conditions

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• 作者：Sophian Sahnoun ; Samir Messaoudi ; ^{samir.messaoudi@u-psud.fr} ; Jean-Franç ; ois Peyrat ; Jean-Daniel Brion ; Mouad Alami ; ^{mouad.alami@u-psud.fr}
• 关键词：Nitriles ; Hydration ; Amides ; Metal-free procedure
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：6 June, 2012
• 卷：53
• 期：23
• 页码：2860-2863
• 文件大小：2467 K

摘要

An efficient hydration reaction of various (hetero)aryl nitriles using Cs₂CO₃ in pyrrolidinone is described. This new metal-free protocol proved to be highly effective and general to synthesize a variety of (hetero)aryl amides.