Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia

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• 作者：Dominic W. Lai ; Thomas P. Loughran Jr. ; Jaroslaw P. Maciejewski ; Sebastian Sasu ; Sophie X. Song ; P.K. Epling-Burnette ; Ronald L. Paquette
• 关键词：Large granular lymphocyte leukemia ; Pure red cell aplasia ; Amegakaryocytic thrombocytopenia ; Cyclosporine ; Glucocorticoids ; Intravenous immunoglobulin
• 刊名：Leukemia Research
• 出版年：2008
• 期刊代码：186_01452126
• 类别：med
• 出版时间：May 2008
• 卷：32
• 期：5
• 页码：823-827
• 文件大小：755 K

摘要

Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia rarely occur concurrently. We report a case in which these disorders were associated with an occult large granular lymphocyte leukemia. The peripheral blood cytopenias improved after glucocorticoids and intravenous immunoglobulin were administered, and response was maintained with cyclosporine. Large granular lymphocyte leukemia should be suspected in the setting of unexplained bone marrow failure.