Implicaci贸n de los quistes de la gl谩ndula pineal en la patogenia de la pubertad precoz central

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• 作者：Z. Garcí ; a Amorí ; np>ap> ; C. Rodrí ; guez Delhip>bp> ; L. Soriano Guill&#233 ; np>cp> ; J.I. Suá ; rez Tomá ; sp>bp> ; I. Riañ ; o Galá ; np>bp>p> ; p>p>isogalan@yahoo.esp>
• 关键词：Quiste pineal ; Pubertad precoz central ; Resonancia magné ; tica
• 刊名：Anales de Pediatr铆a
• 出版年：2010
• 期刊代码：pca47_16954033
• 类别：med
• 出版时间：June 2010
• 卷：72
• 期：6
• 页码：420-423
• 文件大小：641 K

摘要

Objective

<p>To describe clinical characteristics of patients with central precocious puberty (CPP) and pineal cyst, whose causal relationship remains unknown.

Method

<p>An observational, multicentre, and retrospective study of patients with CPP and pineal cyst was carried out.

Results

<p>We recorded four girls, aged between 2鈥? years, diagnosed with CPP, without other medical problems, with the finding of an asymptomatic pineal cyst bigger than 5脳5 mm in Magnetic Resonance Imaging (MRI). All of them were treated with GnRH agonists with regression of pubertal symptoms. Three of the patients had no changes on pineal cyst follow up with successive imaging. In the other, the pineal cyst disappeared after four years.

Comments

<p>We review the epidemiological data and clinical evolution of pineal cysts and the possible mechanisms involved in central precocious puberty.