Pubertad precoz central: aspectos epidemiol贸gicos, etiol贸gicos y diagn贸stico-terap茅uticos

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• 作者：L. Soriano-Guill&#233 ; np>ap> ; J. Argentep>bp>p> ; p>p>argentefen@terra.esp>
• 关键词：Pubertad precoz central
• 刊名：Anales de Pediatr铆a
• 出版年：2011
• 期刊代码：pca47_16954033
• 类别：med
• 出版时间：May 2011
• 卷：74
• 期：5
• 页码：336.e1-336.e13
• 文件大小：368 K

摘要

<p>Central precocious puberty (CPP) is a rare disease with female predominance and a higher incidence among adopted children. Of idiopathic aetiology in most cases, in the past few years the first mutations in patients with CPP have been described.<p>The prevalence of organic disease is notably lower among girls with CPP. However, no predictors have been described to select which kind of girls should undergo an imaging tests. Although the sensitivity of the determination of basal LH as a marker of CPP has improved with the new techniques, to date, the LH peak after LHRH stimulation test remains the gold standard for the diagnosis of CPP. Finally, the use of GnRH analogues has shown to be particularly effective in the treatment of CPP patients less than 6 years-old.