Synthesis, characterization, and structure of a new N-nitrosamine of cyclam (1,4,8,11-tetraazacyclotetradecane)

详细信息	查看全文 | 推荐本文 |

• 作者：Sousa ; Alda Karine M.H. ; Sousa ; Jackson R. ; Santiago ; Marcelo O. ; Longhinotti ; Elisane ; Batista ; Alzir A. ; et. al.
• 关键词：N-Nitrosamine ; Cyclam ; Photoreactivity ; NO release
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：March 14, 2005
• 卷：46
• 期：11
• 页码：1889-1891
• 文件大小：145 K

摘要

A novel N-nitrosamine of cyclam has been synthesized. The N芒芒芒N bond lengths values, as determined from the X-ray crystal structure, fall in the 1.318(2) and 1.320(2)芒芒芒 range, smaller than the ones expected for the N芒芒芒N single bond. The N芒芒芒NO bond angles are in the 115.0(1)芒芒 and 114.8(1)芒芒 range. The 芒芒NO, 芒芒NN, and 芒芒N芒芒芒NO vibrational modes were observed in the infrared spectrum at 1454, 1139, and 555cm^芒芒芒1, respectively. The photolysis of the cyclam(NO)₄ compound gives rise to the nitrosyl release through an heterolytic cleavage of the N芒芒芒NO bonds, as indicated by the appearance of the 芒芒NO⁺ band at 2228cm^芒芒芒1 at the expense of decreasing the 芒芒NO, 芒芒NN, and 芒芒N芒芒芒NO bands.