Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-na茂ve epilepsy patients

详细信息	查看全文 | 推荐本文 |

• 作者：Jounhong Ryan Cho^a ; ^b ; ¹ ; Dae Lim Koo^a ; ¹ ; Eun Yeon Joo^a ; So Mi Yoon^a ; Eunji Ju^c ; James Lee^d ; Dae Young Kim^a ; Seung Bong Hong^a ; ^b ; ^{sbhong@skku.edu} ; ^{sbhong2010@hotmail.com}
• 关键词：Antiepileptic drugs ; Levetiracetam ; EEG ; Quantitative analysis ; Cognitive function
• 刊名：Clinical Neurophysiology
• 出版年：2012
• 期刊代码：61_13882457
• 类别：med
• 出版时间：May, 2012
• 卷：123
• 期：5
• 页码：883-891
• 文件大小：838 K

摘要

Objective

To investigate the cognitive effect of levetiracetam (LEV) monotherapy with quantitative electroencephalogram (EEG) analysis and neuropsychological (NP) tests.

Methods

Twenty-two drug-na茂ve epilepsy patients were enrolled. EEG recordings were performed before and after LEV therapy. Relative power of discrete frequency bands was computed, as well as alpha peak frequency (APF) at occipital electrodes. Eighteen patients performed a battery of NP tests twice across LEV treatment.

Results

LEV therapy decreased the power of delta (1-3 Hz, p < 0.01) and theta (3-7 Hz, p < 0.05) bands and increased that of alpha-2 (10-13 Hz, p < 0.05) and beta-2 (19-24 Hz, p < 0.05) bands. Region-specific spectral change was observed: delta power change was significant in fronto-polar region, theta in anterior region, alpha-2 in broad region, and beta-2 in left fronto-central region. APF change was not significant. Improvement in diverse NP tests requiring attention, working memory, language and executive function was observed. Change in theta, alpha-2, and beta-2 power was correlated with improvement in several NP tests.

Conclusions

Our data suggest LEV is associated with acceleration of background EEG frequencies and improved cognitive function. Change in frequency band power could predict improvement in several cognitive domains across LEV therapy.

Significance

Combined study of quantitative EEG analysis and NP tests can be useful in identifying cognitive effect of antiepileptic drugs.