Ionic liquid anchored substrate for enzyme catalysed kinetic resolution
- 作者：Prashant U. Naik ; Susheel J. Nara ; Jitendra R. Harjani ; Manikrao M. Salunkhe
- 关键词：Task specific ionic liquids ; Ibuprofen ; Resolution ; Enantioselective hydrolysis
- 刊名：Journal of Molecular Catalysis B ; Enzymatic
- 出版年：2007
- 期刊代码：55_13811177
- 类别：ce
- 出版时间：1 March 2007
- 卷：44
- 期：3-4
- 页码：93-98
- 文件大小：257 K
摘要
A hydroxyl group appended task specific ionic liquid was designed and synthesised. The ionic liquid was used as a vehicle for the substrate of our interest for lipase catalysed kinetic resolution. The ionic liquid anchored ibuprofen underwent Candida antarctica lipase catalysed hydrolysis yielding the S-enantiomer. The strategy facilitated easy post-resolution isolation of the enantiomers and also carries the prospect of recyclability.