Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states?

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• 作者：Carolina Valerio^a ; ^b ; ^{carol.ac.psico@gmail.com} ; Juliana Belo Diniz^a ; ^b ; Victor Fossaluza^b ; ^c ; Maria Alice de Mathis^a ; ^b ; Cristina Belotto-Silva^a ; ^b ; Marinê ; s Alves Joaquim^a ; ^b ; Eurí ; pedes Constantino Miguel Filho^a ; ^b ; Roseli Gedanke Shavitt^a ; ^b
• 关键词：Obsessive&ndash ; compulsive disorder ; Psychiatric comorbidities ; Treatment response
• 刊名：Journal of Affective Disorders
• 出版年：2012
• 期刊代码：141_01650327
• 类别：med
• 出版时间：July, 2012
• 卷：139
• 期：2
• 页码：187-192
• 文件大小：239 K

摘要

Background

Obsessive-compulsive disorder (OCD) is a chronic condition that normally presents high rates of psychiatric comorbidity. Depression, tic disorders and other anxiety disorders are among the most common comorbidities in OCD adult patients. There is evidence that the higher the number of psychiatric comorbidities, the worse the OCD treatment response. However, little is known about the impact of OCD treatment on the outcome of the psychiatric comorbidities usually present in OCD patients. The aim of this study was to investigate the impact of exclusive, conventional treatments for OCD on the outcome of additional psychiatric disorders of OCD patients, detected at baseline.

Methods

Seventy-six patients with primary OCD admitted to the treatment protocols of the Obsessive-Compulsive Spectrum Disorders Program between July 2007 and December 2009 were evaluated at pre-treatment and after 12 months. Data were analyzed to verify possible associations between OCD treatment response and the outcome of psychiatric comorbidities.

Results

Results showed a significant association between OCD treatment response and improvement of major depression and dysthymia (p-value = 0.002), other anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, posttraumatic stress disorder, panic disorder, agoraphobia and anxiety disorder not otherwise specified) (p-value = 0.054) and tic disorders (p-value = 0.043).

Limitations

This is an open, non-blinded study, without rating scales for comorbid conditions. Further research is necessary focusing on the possible mechanisms by which OCD treatment could improve these specific disorders.

Conclusions

Our results suggest that certain comorbid disorders may benefit from OCD-targeted treatment.