Distribution and metabolic syndrome correlates of plasma C-reactive protein in biracial (Black-White) younger adults: The Bogalusa Heart Study

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• 作者：D.A. P.R. Sathanur ; R. Srinivasan ; J-. Xu ; S. Li ; W. Chen and G.S. Berenson
• 刊名：Annals of Epidemiology
• 出版年：2005
• 期刊代码：15_10472797
• 类别：med
• 出版时间：2005
• 卷：15
• 期：8
• 页码：641
• 文件大小：51 K

摘要

Purpose

The association between plasma C-reactive protein (CRP), a marker of inflammation, and the metabolic syndrome is well recognized. However, information is scant regarding the component of metabolic syndrome that is critical in modulating CRP levels in younger adults.

Methods

This aspect was examined in a biracial (Black-White) community based sample of 1083 younger adults (mean age: 36.1 years, 71%white, 45%male) enrolled in the Bogalusa Heart Study. Plasma CRP along with metabolic syndrome variables was measured.

Results

CRP levels showed a significant race (black>white) and gender (female>male) differences; and relates to measures of obesity (BMI and waist circumference), blood pressure (systolic, diastolic, and mean arterial blood pressure), lipoproteins (LDL cholesterol, HDL cholesterol, triglycerides, total cholesterol/HDL cholesterol ratio), glucose homeostasis (insulin, glucose, homeostasis model assessment of insulin resistance index [HOMA-IR]), and uric acid, after adjusting for age, race, gender and cigarette smoking. Further, CRP levels increased with increasing number of metabolic syndrome risk factors, as defined by National Cholesterol Education Program ATP III, regardless of race and gender (p for trend, <0.0001). In a multivariate analysis, waist, female gender, total cholesterol/HDL cholesterol ratio, mean arterial blood pressure and HOMA-IR entered into the model in that order and explained 23.0%of the variance. Of note, waist accounted for 13.4%variance in the CRP levels, whereas HOMA-IR only 0.35%.

Conclusion

CRP levels differ among race and gender groups, and correlates to metabolic syndrome variables. In addition, these findings strongly suggest that although obesity and insulin resistance are the underlying features of the metabolic syndrome, the former appears to be the mediator of CRP levels.