Optimized Liebeskind-Srogl coupling reaction between dihydropyrimidines and tributyltin compounds

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• 作者：Qi Sun^a ; ^b ; Franck Suzenet^b ; ^{franck.suzenet@univ-orleans.fr} ; Gé ; rald Guillaumet^b
• 关键词：Liebeskind&ndash ; Srogl reaction ; 2-Aryl-1 ; 4-dihydropyrimidines ; Dihydropyrimidinthiones ; Tributyltin derivatives
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：30 May, 2012
• 卷：53
• 期：22
• 页码：2694-2698
• 文件大小：1181 K

摘要

We developed an optimized Liebeskind-Srogl reaction in order to synthesize potentially biologically active 2-aryl-1,4-dihydropyrimidines. The pallado-catalyzed cross-coupling reaction between dihydropyrimidines and tributyltin derivatives appears particularly efficient (67-95%yields) when using CuBr路Me₂S as the copper cofactor.