Association of polymorphisms in CTLA-4, IL-1ra and IL-1β genes with multiple sclerosis in Serbian population

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• 作者：Evica Dinč ; i&#x107 ; Maja Ž ; ivkovi&#x107 ; Aleksandra Stankovi&#x107 ; Dragana Obradovi&#x107 ; Dragan Alavanti&#x107 ; Vladimir Kosti&#x107 ; and Ranko Raič ; evi&#x107
• 关键词：IL-1β ; IL-1ra ; CTLA-4 ; Gene ; Polymorphisms ; Multiple sclerosis
• 刊名：Journal of Neuroimmunology
• 出版年：2006
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：August 2006
• 卷：177
• 期：1-2
• 页码：146-150
• 文件大小：122 K

摘要

We have investigated separate as well as combined influence of IL-1β TaqI, IL-1ra VNTR and CTLA-4 + 49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-1ra allele 2 (OR = 2.2, CI = 1.3–3.7, p = 0.003) and CTLA-4 + 49 AA genotype (OR = 2.0, CI = 1.2–3.5, p = 0.01) as well as their combined effect (OR = 4.4, CI = 2.0–9.7, p = 0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations.