Selective transport of staphylococcal enterotoxin A through in vitro generated human M cells
- 作者：Marc Maresca ; Eliane Dumay ; Jacques Fantini ; Bertr ; Caporiccio
- 关键词：Staphylococcal enterotoxin ; SEA ; Caco-2 ; M cells ; Transcytosis
- 刊名：Microbes and Infection
- 出版年：2007
- 期刊代码：65_12864579
- 类别：imm
- 出版时间：October 2007
- 卷：9
- 期：12-13
- 页码：1507-1510
- 文件大小：163 K
摘要
Staphylococcal enterotoxins are responsible for food poisoning and toxic shock syndrome due to their superantigen activity on T cells. Although their activity necessarily involves passage through the intestinal epithelium, little is known about this critical step. In the present study, we compared the in vitro transport of staphylococcal enterotoxin A through human intestinal absorptive and M cells. We found that the transport of the toxin through M cells was polarized and temperature-sensitive, in contrast with the less efficient transport of the toxin by absorptive cells. These data suggest the involvement of M cells in the intestinal absorption of staphylococcal enterotoxins.