Enhancing reproducibility of fMRI statistical maps using generalized canonical correlation analysis in NPAIRS framework

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• 作者：Babak Afshin-Pour^a ; ^b ; Gholam-Ali Hossein-Zadeh^a ; ^c ; Stephen C. Strother^b ; ^d ; Hamid Soltanian-Zadeh^a ; ^c ; ^e ; ^{hamids@rad.hfh.edu}
• 关键词：Canonical variant analysis (CVA) ; Functional magnetic resonance imaging (fMRI) ; Generalized canonical correlation analysis (gCCA) ; Multivariate analysis techniques ; Reproducibility
• 刊名：NeuroImage
• 出版年：2012
• 期刊代码：83_10538119
• 类别：neu
• 出版时间：1 May, 2012
• 卷：60
• 期：4
• 页码：1970-1981
• 文件大小：1206 K

摘要

Common fMRI data processing techniques usually minimize a temporal cost function or fit a temporal model to extract an activity map. Here, we focus on extracting a highly, spatially reproducible statistical parametric map (SPM) from fMRI data using a cost function that does not depend on a model of the subjects' temporal response. Based on a generalized version of canonical correlation analysis (gCCA), we propose a method to extract a highly reproducible map by maximizing the sum of pair-wise correlations between some maps. In a group analysis, each map is calculated from a linear combination of fMRI scans of a subset of subjects under study. The proposed method is applied to BOLD fMRI datasets without any spatial smoothing from 10 subjects performing a simple reaction time (RT) task. Using the NPAIRS split-half resampling framework with a reproducibility measure based on SPM correlations, we compare the proposed approach with canonical variate analysis (CVA) and a simple general linear model (GLM). gCCA provides statistical parametric maps with higher reproducibility than CVA and GLM with correlation reproducibilities across independent split-half SPMs of 0.78, 0.46, and 0.41, respectively. Our results show that gCCA is an efficient approach for extracting the default mode network, assessing brain connectivity, and processing event-related and resting-state datasets in which the temporal BOLD signal varies from subject to subject.